| # | Name | Team | Opp | Date | Score | AB | H | RBI | HR | R | BB | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Ron Prieto | PHI | TBA | April 11, 2166 | 9-7 | 4 | 4 | 7 | 3 | 4 | 0 | 124 |
| 2 | Orlando Rodríguez | VAN | TEX | May 7, 2166 | 14-3 | 4 | 4 | 6 | 1 | 4 | 1 | 112 |
| 3 | Greg Colón | MON | CHW | April 25, 2166 | 12-11 | 6 | 3 | 6 | 3 | 4 | 2 | 107 |
| 4 | Rubén Jiménez | TBA | DET | April 5, 2166 | 8-1 | 3 | 3 | 6 | 3 | 3 | 1 | 107 |
| 5 | Tom Brown | COL | STL | May 26, 2166 | 16-5 | 4 | 3 | 7 | 3 | 3 | 0 | 105 |
| 6 | Jeremy Lucas Jr. | CHW | ATL | June 1, 2166 | 13-2 | 6 | 5 | 5 | 2 | 3 | 0 | 102 |
| 7 | Miguel Rodríguez | OAK | LAD | April 12, 2166 | 14-6 | 5 | 4 | 6 | 1 | 3 | 1 | 101 |
| 8 | Brian Harvey | CHC | MON | June 18, 2166 | 10-4 | 3 | 2 | 5 | 2 | 4 | 3 | 100 |
| 9 | Abdur Salam Khattak | BOS | SD | April 11, 2166 | 9-3 | 5 | 4 | 5 | 3 | 3 | 0 | 99 |
| 10 | Guillermo Hernández | MIN | LAA | April 17, 2166 | 19-6 | 6 | 5 | 4 | 2 | 3 | 0 | 95 |
| 11 | Rubén Flores | SEA | SF | May 26, 2166 | 20-0 | 5 | 3 | 6 | 2 | 3 | 1 | 94 |
| 12 | Eduardo Olivarez | LAA | KC | May 2, 2166 | 10-3 | 5 | 4 | 5 | 2 | 3 | 0 | 94 |
| 13 | Jaime Soto | CHW | SD | May 8, 2166 | 15-13 | 5 | 4 | 3 | 3 | 4 | 0 | 92 |
| 14 | Albert Montgomery | MIL | NYM | April 22, 2166 | 7-6 | 7 | 4 | 6 | 2 | 2 | 1 | 91 |
| 15 | Kevin Robertson | NYY | SF | May 12, 2166 | 9-0 | 4 | 3 | 5 | 3 | 3 | 0 | 91 |
| 16 | Kenny Thebeau | PHI | LAA | April 20, 2166 | 10-8 | 4 | 3 | 5 | 2 | 3 | 1 | 91 |
| 17 | Jorge Acosta | COL | NYM | May 9, 2166 | 8-1 | 4 | 3 | 5 | 3 | 3 | 0 | 91 |
| 18 | William Márquez | PIT | ATL | May 1, 2166 | 9-4 | 4 | 3 | 5 | 2 | 3 | 1 | 91 |
| 19 | Bob Grenier | MIL | ARI | May 19, 2166 | 14-0 | 3 | 2 | 6 | 2 | 3 | 1 | 90 |
| 20 | Charles Grzanich | MIN | TBA | June 7, 2166 | 12-6 | 5 | 5 | 5 | 0 | 2 | 0 | 89 |
| 21 | Jorge Lucero | TBA | WAS | May 31, 2166 | 8-4 | 4 | 4 | 3 | 2 | 3 | 1 | 89 |
| 22 | Travis Winston | TEX | PIT | April 17, 2166 | 10-3 | 3 | 3 | 5 | 2 | 2 | 1 | 88 |
| 23 | Anthony Clark | LAD | NYY | May 7, 2166 | 9-5 | 5 | 4 | 4 | 2 | 3 | 0 | 87 |
| 24 | Robert Montés | CLE | LAD | June 30, 2166 | 8-7 | 5 | 4 | 4 | 2 | 3 | 0 | 87 |
| 25 | Paul Reece | MIN | LAA | April 17, 2166 | 19-6 | 5 | 4 | 4 | 1 | 3 | 1 | 87 |
| 26 | Pedro Serrano | SD | NYY | May 28, 2166 | 7-1 | 4 | 3 | 4 | 2 | 4 | 0 | 86 |
| 27 | Guillermo Franco | OAK | SD | May 4, 2166 | 11-0 | 3 | 3 | 3 | 2 | 3 | 2 | 86 |
| 28 | Arthur Graham | LAA | MON | May 3, 2166 | 7-0 | 3 | 3 | 3 | 2 | 3 | 2 | 86 |
| 29 | Steven Heredia | TEX | ARI | April 6, 2166 | 9-5 | 4 | 3 | 5 | 2 | 3 | 0 | 86 |
| 30 | George Whitten | WAS | COL | May 29, 2166 | 16-6 | 6 | 4 | 5 | 1 | 3 | 0 | 85 |