| # | Name | Team | Opp | Date | Score | IP | R | H | HR | BB | K | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Doug Williamson | PIT | ARI | April 20, 2166 | 2-1 | 9.0 | 0 | 1 | 0 | 1 | 7 | 97 |
| 2 | Yaichiro Kaneko | SD | BOS | April 10, 2166 | 8-0 | 9.0 | 0 | 3 | 0 | 0 | 8 | 96 |
| 3 | Jeffrey Watson | KC | BOS | June 14, 2166 | 2-0 | 10.0 | 0 | 3 | 0 | 2 | 5 | 95 |
| 4 | Roberto Lemus | ARI | ATL | June 19, 2166 | 5-1 | 8.2 | 1 | 3 | 0 | 1 | 10 | 91 |
| 5 | Ray Belding | BOS | CHW | May 10, 2166 | 0-1 | 8.1 | 0 | 2 | 0 | 0 | 3 | 89 |
| 6 | Kyle O'Lowry | PIT | NYY | June 16, 2166 | 2-1 | 9.0 | 1 | 5 | 0 | 1 | 10 | 89 |
| 7 | Ovidio Rosado | ARI | PIT | April 21, 2166 | 7-1 | 8.1 | 1 | 4 | 0 | 0 | 9 | 88 |
| 8 | Max Norman | ARI | NYY | April 13, 2166 | 1-0 | 8.0 | 0 | 2 | 0 | 1 | 6 | 88 |
| 9 | Gary Hoffman | TOR | COL | May 14, 2166 | 3-0 | 8.0 | 0 | 2 | 0 | 2 | 8 | 88 |
| 10 | Michael Chouda | CHC | STL | April 16, 2166 | 8-0 | 8.2 | 0 | 1 | 0 | 4 | 6 | 88 |
| 11 | Michael Chouda | CHC | STL | May 1, 2166 | 6-1 | 6.2 | 0 | 1 | 0 | 0 | 10 | 88 |
| 12 | Pedro López | DET | SEA | June 20, 2166 | 1-0 | 8.0 | 0 | 3 | 0 | 0 | 5 | 87 |
| 13 | Ray Belding | BOS | ARI | May 5, 2166 | 11-1 | 9.0 | 1 | 3 | 1 | 0 | 8 | 87 |
| 14 | Stan O'Mackesey | VAN | NYY | April 18, 2166 | 0-1 | 8.1 | 0 | 3 | 0 | 1 | 5 | 87 |
| 15 | Kyle Prince | TOR | BOS | May 28, 2166 | 1-0 | 8.2 | 0 | 3 | 0 | 2 | 5 | 87 |
| 16 | Florentin Coste | KC | STL | April 25, 2166 | 5-0 | 8.0 | 0 | 2 | 0 | 1 | 4 | 86 |
| 17 | Ray Belding | BOS | KC | June 14, 2166 | 0-2 | 8.1 | 0 | 5 | 0 | 0 | 6 | 86 |
| 18 | Yaichiro Kaneko | SD | ATL | April 4, 2166 | 3-0 | 8.2 | 0 | 6 | 0 | 1 | 8 | 86 |
| 19 | Thurman Ferris | CHC | OAK | May 25, 2166 | 7-0 | 8.0 | 0 | 1 | 0 | 3 | 6 | 86 |
| 20 | Gabriel Reyes | WAS | KC | May 26, 2166 | 0-1 | 8.2 | 1 | 2 | 1 | 2 | 11 | 86 |
| 21 | Jeffrey Watson | KC | STL | May 28, 2166 | 1-0 | 8.0 | 0 | 4 | 0 | 2 | 10 | 86 |
| 22 | Roberto Lemus | ARI | ATL | April 19, 2166 | 4-0 | 9.0 | 0 | 4 | 0 | 4 | 8 | 86 |
| 23 | Ingo van Aardschot | LAA | TBA | May 19, 2166 | 11-2 | 7.0 | 0 | 1 | 0 | 1 | 7 | 85 |
| 24 | Jesse Ladds | SEA | MIA | April 28, 2166 | 6-0 | 6.2 | 0 | 1 | 0 | 0 | 7 | 85 |
| 25 | Jonathan Sharp | CHW | COL | June 26, 2166 | 1-0 | 8.0 | 0 | 2 | 0 | 1 | 3 | 85 |
| 26 | Jake Ladd | LAD | SF | May 31, 2166 | 8-1 | 7.0 | 0 | 3 | 0 | 0 | 9 | 85 |
| 27 | Gary Hoffman | TOR | HOU | May 24, 2166 | 8-1 | 9.0 | 1 | 6 | 0 | 0 | 5 | 84 |
| 28 | Robert Douglas | MIL | PIT | May 23, 2166 | 7-2 | 7.0 | 0 | 2 | 0 | 1 | 8 | 84 |
| 29 | Edmond Alexander | MIL | NYM | May 30, 2166 | 8-1 | 9.0 | 1 | 4 | 0 | 2 | 5 | 84 |
| 30 | Gabriel Reyes | WAS | STL | May 15, 2166 | 1-0 | 9.0 | 0 | 4 | 0 | 5 | 7 | 83 |