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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sa, Zhuo-cheng | SP | Anderson Joes | 23 | 09/18/2035 | Sanchung | TPE | Switch | Right | 6' 9" | 200 lbs | - |
| Saito, Aki | 2B | St. Joseph Butchers | 24 | 04/03/2034 | Shinjo | JPN | Right | Right | 6' 1" | 195 lbs | - |
| Sakellaridis, Alexander | SP | St. Joseph Butchers | 24 | 02/25/2035 | Piryíon | GRE | Right | Right | 6' 2" | 185 lbs | - |
| Salas, Júlio | 3B | Columbus Patriot Pandas | 24 | 07/02/2034 | Alcalde Díaz | PAN | Right | Right | 6' 2" | 200 lbs | - |
| Salsbery, Hagen | RP | Corpus Christi Crawfish | 24 | 04/21/2034 | Greyabbey | NIR | Right | Right | 6' 4" | 185 lbs | - |
| Sandlin, Craig | SP | Free Agent | 25 | 09/19/2033 | Coquitlam | CAN | Left | Left | 6' 2" | 190 lbs | - |
| Sandoval, Ismael | RP | Kamloops Moops | 25 | 01/08/2034 | Carolina | PUR | Left | Right | 6' 6" | 200 lbs | - |
| Sangha, Avabhasita | RP | Bismarck Churchills | 27 | 04/29/2031 | Vaghodia INA | IND | Left | Left | 6' 1" | 180 lbs | - |
| Santos, Alfredo | RP | Jamestown Comets | 21 | 06/12/2037 | Puebla | MEX | Right | Right | 6' 4" | 195 lbs | - |
| Sarazin, Duane | LF | Trenton Generals | 23 | 08/11/2035 | Lethbridge | CAN | Left | Left | 6' 3" | 200 lbs | - |
| Sarazin, Eddy | RP | Parker PIlots | 25 | 01/22/2034 | Burnaby | CAN | Left | Left | 6' 7" | 200 lbs | - |
| Sardeson, Jeremy | 2B | Duluth Dragons | 28 | 12/04/2030 | Sederot | ISR | Right | Right | 6' 1" | 200 lbs | - |
| Scholes, Jorge | C | Free Agent | 27 | 02/13/2032 | Louisville | USA | Right | Right | 6' 0" | 200 lbs | - |
| Schroder, Dagobert | RP | Sioux City Xplorers | 24 | 01/06/2035 | Bretzenheim | GER | Switch | Left | 6' 0" | 180 lbs | - |
| Scott, Jeremy | 3B | Duluth Dragons | 27 | 04/12/2031 | Haifa | ISR | Right | Right | 6' 2" | 200 lbs | - |
| Seguin, Chris | RP | Burlington Big Eyed Fish | 26 | 05/30/2032 | Calgary | CAN | Left | Right | 6' 4" | 200 lbs | - |
| Segura, Fernando | 2B | Anderson Joes | 21 | 03/06/2037 | Bayamón | PUR | Left | Right | 6' 6" | 200 lbs | - |
| Selmi, Mitchell | LF | Trenton Generals | 22 | 04/21/2036 | Vereeniging | RSA | Right | Right | 6' 2" | 190 lbs | - |
| Sen, Cheng-en | C | Duluth Dragons | 27 | 09/04/2031 | Taipei | TPE | Switch | Right | 6' 1" | 200 lbs | - |
| Seow, Yi-mou | C | Medicine Hat Flaming Nukes | 26 | 05/17/2032 | Anju | CHN | Right | Right | 6' 5" | 200 lbs | - |
| Seta, Moana | RF | Medicine Hat Flaming Nukes | 27 | 09/20/2031 | Fagaalu | ASA | Right | Right | 6' 7" | 200 lbs | - |
| Sevier, Erwin | RP | Santa Cruz Spartans | 23 | 08/02/2035 | Saginaw | USA | Right | Right | 6' 9" | 200 lbs | - |
| Seánez, Alberto | SS | Winston-Salem Warthogs | 24 | 09/23/2034 | Albuquerque | USA | Switch | Right | 6' 2" | 190 lbs | - |
| Shabi, Cachari | SS | St. Joseph Butchers | 24 | 08/05/2034 | Medak | IND | Left | Right | 6' 1" | 190 lbs | - |
| Shaw, Shi-ping | CL | Charleston Clippers | 27 | 01/13/2032 | Huangshi | CHN | Left | Left | 6' 2" | 200 lbs | - |
| Shaw, Wes | SP | Louisville Fire | 26 | 03/18/2032 | Brentwood | USA | Right | Right | 6' 4" | 200 lbs | - |
| Shelton, Rob | RP | Bismarck Churchills | 27 | 09/17/2031 | Clinton | USA | Right | Right | 6' 4" | 200 lbs | - |
| Shemilt, Bartlae | SP | Free Agent | 28 | 10/04/2030 | Rushton Spencer | ENG | Right | Right | 6' 8" | 200 lbs | - |
| Shetty, Garbhaka | SP | Charleston Clippers | 26 | 10/30/2032 | Kiraoli | IND | Right | Right | 6' 1" | 185 lbs | - |
| Shinn, Brent | RP | Free Agent | 28 | 05/31/2030 | Queens | USA | Right | Right | 6' 6" | 200 lbs | - |
| Shiu, Ming | SP | Corpus Christi Crawfish | 24 | 07/10/2034 | Nantongkuang | CHN | Left | Left | 6' 8" | 200 lbs | - |
| Shoup, Ed | C | Medicine Hat Flaming Nukes | 27 | 11/25/2031 | Savannah | USA | Left | Right | 6' 0" | 200 lbs | - |
| Sihâbeddîn, Oguz | SP | Columbus Patriot Pandas | 23 | 03/08/2035 | Sarikaya | TUR | Right | Right | 6' 5" | 200 lbs | - |
| Simancas, Anastasio | C | Trenton Generals | 21 | 08/16/2037 | Bethlehem | USA | Right | Right | 5' 11" | 185 lbs | - |
| Simmons, Joe | SP | Free Agent | 27 | 07/02/2031 | Mangilao | GUM | Left | Right | 6' 4" | 200 lbs | - |
| Simon, Michael | C | Free Agent | 27 | 05/23/2031 | Stonybrook-Wilshire | USA | Right | Right | 6' 0" | 200 lbs | - |
| Sin, Seu | 3B | Charleston Clippers | 27 | 08/06/2031 | Ulsan | KOR | Right | Right | 6' 2" | 200 lbs | - |
| Sin, Yeong-kil | RP | Duluth Dragons | 27 | 06/08/2031 | Toksangwan | PRK | Switch | Left | 6' 4" | 200 lbs | - |
| Skinner, Marco | 3B | New Bern Bears | 22 | 08/11/2036 | Sydney | AUS | Switch | Right | 6' 1" | 175 lbs | - |
| Slattery, Paul | C | Anderson Joes | 23 | 10/18/2035 | Orem | USA | Right | Right | 6' 1" | 200 lbs | - |
| Smith, Héctor | CL | Jamestown Comets | 21 | 05/27/2037 | West Springfield | USA | Right | Right | 6' 3" | 185 lbs | - |
| Smith, Michael | 2B | Medicine Hat Flaming Nukes | 26 | 08/08/2032 | Lod | ISR | Right | Right | 6' 2" | 190 lbs | - |
| Smith, Will | RP | Santa Cruz Spartans | 25 | 09/28/2033 | Oak Grove | USA | Switch | Right | 6' 6" | 200 lbs | - |
| Snider, Bob | RP | Medicine Hat Flaming Nukes | 26 | 02/28/2032 | Canton | USA | Left | Left | 6' 8" | 200 lbs | - |
| Snow, Mike | SP | Santa Cruz Spartans | 25 | 09/06/2033 | Oakville | USA | Left | Left | 6' 1" | 180 lbs | - |
| Solís, Ramón | RP | Corpus Christi Crawfish | 24 | 10/28/2034 | Mayagüez | PUR | Right | Right | 6' 3" | 195 lbs | - |
| Solíz, Iván | SP | Kamloops Moops | 24 | 02/16/2035 | Tucson | USA | Right | Right | 6' 2" | 190 lbs | - |
| Soto, Andrés | LF | Corpus Christi Crawfish | 23 | 08/11/2035 | Oakland | USA | Left | Right | 5' 10" | 175 lbs | - |
| Soto, Felipe | SP | Trois-Rivieres Salmon Kings | 26 | 09/24/2032 | San Juan | PUR | Left | Left | 6' 1" | 200 lbs | - |
| Soukup, Larry | SP | Santa Cruz Spartans | 23 | 06/14/2035 | Los Angeles | USA | Left | Right | 6' 5" | 200 lbs | - |
| Soumodip, Ettan | SS | Louisville Fire | 25 | 10/11/2033 | Bharwari | IND | Right | Right | 6' 1" | 190 lbs | - |
| Souza, Jorge | RP | Charleston Clippers | 23 | 04/21/2035 | Florida | CUB | Right | Right | 6' 4" | 200 lbs | - |
| Spratt, Ron | RF | Duluth Dragons | 26 | 06/24/2032 | Beloeil | CAN | Right | Right | 6' 2" | 195 lbs | - |
| Stafford, George | CL | Kamloops Moops | 22 | 03/10/2036 | Arvada | USA | Right | Right | 6' 1" | 180 lbs | - |
| Stanley, Clement | RP | Weymouth Irish | 26 | 08/06/2032 | Qiryat Yam | ISR | Right | Right | 6' 0" | 185 lbs | - |
| Stanley, Eric | C | Burlington Big Eyed Fish | 28 | 11/07/2030 | Murfreesboro | USA | Switch | Right | 6' 3" | 200 lbs | - |
| Stasi, Agatone | RP | Free Agent | 27 | 10/30/2031 | Piryíon | GRE | Right | Right | 6' 4" | 200 lbs | - |
| Steel, Justin | CF | Peoria Spirits | 26 | 05/04/2032 | Hopwood | USA | Switch | Right | 6' 1" | 200 lbs | - |
| Steele, Dalton | RP | Duluth Dragons | 28 | 07/29/2030 | Arlington | USA | Right | Right | 6' 1" | 195 lbs | - |
| Stevens, Jack | LF | Louisville Fire | 27 | 08/04/2031 | North Atlanta | USA | Right | Right | 6' 1" | 200 lbs | - |
| Stewart, Blaine | SP | Frederick Travelers | 22 | 12/27/2036 | Salem | USA | Left | Left | 6' 3" | 195 lbs | - |
| Stone, Joe | RP | Carson City Gamblers | 22 | 07/05/2036 | Nanaimo | CAN | Left | Left | 6' 2" | 185 lbs | - |
| Strom, Brent | SP | Free Agent | 29 | 06/18/2029 | Norman | USA | Right | Right | 6' 3" | 190 lbs | - |
| Strunk, Thomas | RP | Weymouth Irish | 27 | 07/23/2031 | Troy | USA | Left | Right | 6' 2" | 200 lbs | - |
| Subbaratnam, Devasarasa | RP | Santa Cruz Spartans | 25 | 08/11/2033 | Bhawri | IND | Left | Left | 6' 6" | 200 lbs | - |
| Sully, Jamie | LF | Duluth Dragons | 25 | 01/22/2034 | Henfield | ENG | Right | Right | 6' 4" | 205 lbs | - |
| Sun, Zhao-jun | RP | Frederick Travelers | 24 | 03/30/2034 | Kinhsia | TPE | Right | Right | 6' 3" | 185 lbs | - |
| Sung, Chong-yee | SP | Burlington Big Eyed Fish | 24 | 02/08/2035 | Changsha | CHN | Right | Right | 6' 3" | 190 lbs | - |
| Surendranath, Amaka | 3B | Bismarck Churchills | 26 | 10/17/2032 | Alang | IND | Switch | Right | 6' 0" | 200 lbs | - |
| Suárez, Alfredo | LF | Reno Aces | 23 | 09/24/2035 | Minneapolis | USA | Left | Right | 6' 3" | 195 lbs | - |
| Sweetapple, Bill | RP | Providence Bees | 26 | 10/09/2032 | Chatham-Kent | CAN | Switch | Right | 5' 11" | 180 lbs | - |
| Sánchez, César | SP | Anderson Joes | 21 | 01/17/2038 | Salinas | USA | Right | Right | 6' 2" | 175 lbs | - |
| Sánchez, Dani | C | Providence Bees | 24 | 09/23/2034 | San Juan | PUR | Right | Right | 6' 6" | 215 lbs | - |
| Sánchez, Fernando | 1B | High Point Hammers | 23 | 02/04/2036 | Havana | CUB | Right | Right | 6' 2" | 200 lbs | - |
| Sánchez, Fernando | RP | Free Agent | 33 | 07/26/2025 | Colón | CRC | Switch | Right | 6' 3" | 200 lbs | - |
| Sánchez, Orlando | SP | Corpus Christi Crawfish | 23 | 05/31/2035 | Nava | MEX | Right | Right | 6' 4" | 200 lbs | - |
| Sánchez, Ricardo | CL | Carson City Gamblers | 22 | 02/10/2037 | Buenos Aires | ARG | Right | Left | 6' 4" | 190 lbs | - |
| Sánz, Carlos | LF | Mississauga Spartans | 27 | 04/25/2031 | Guayanilla | PUR | Right | Right | 6' 1" | 200 lbs | - |
