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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Postseason Career Leaderboard |
|---|---|---|---|---|
| 1 | Xiao-shuang Chi# | 0.529 | 2049 | |
| 2 | Juan Oliveira# | 0.574 | 2058 | |
| 3 | Paul Jones | 0.587 | 2035 | |
| 4 | Sotaro Abe# | 1.080 | 2054 | |
| 5 | José Vázquez | 1.125 | 2047 | |
| 6 | Brian Chappell# | 1.174 | 2054 | |
| 6 | Jorge Santos# | 1.174 | 2048 | |
| 6 | Raúl Díaz | 1.174 | 2042 | |
| 9 | Josh Brown | 1.191 | 2032 | |
| 10 | Daniel Thornton# | 1.446 | 2054 | |
| 11 | Jesús Duarte | 1.565 | 2028 | |
| 12 | Eustace Tilley | 1.588 | 2041 | |
| 12 | Takanori Goto | 1.588 | 2052 | |
| 14 | Juan Acevedo | 1.662 | 2026 | |
| 15 | Yun Zhang | 1.688 | 2053 | |
| 15 | Ramón Negrón | 1.688 | 2038 | |
| 17 | Chris Kelly | 1.742 | 2032 | |
| 18 | Justin Archer | 1.761 | 2036 | |
| 18 | Carlos Guillén | 1.761 | 2030 | |
| 20 | Manny Gabriel | 1.800 | 2033 | |
| 20 | Francisco Estrada | 1.800 | 2047 | |
| 20 | Jorge Alvarado | 1.800 | 2044 | |
| 23 | Celestino Balazes | 1.957 | 2025 | |
| 24 | José Hernández | 2.015 | 2027 | |
| 24 | Quintin Moore | 2.015 | 2029 | |
| 26 | Orlando Pérez | 2.160 | 2041 | |
| 27 | Héctor Acevedo | 2.177 | 2026 | |
| 28 | Luis Valentín | 2.204 | 2027 | |
| 29 | Gus Garza | 2.250 | 2041 | |
| 29 | Jimi Thing | 2.250 | 2029 | |
| 31 | Brady Miller# | 2.288 | 2051 | |
| 32 | Nadir Akili | 2.348 | 2034 | |
| 32 | Andresa Pires | 2.348 | 2053 | |
| 34 | Jorge Váquez | 2.400 | 2043 | |
| 35 | Chet Parrish | 2.411 | 2033 | |
| 36 | Ramón Esesbeno | 2.455 | 2026 | |
| 36 | Mauro Valentín | 2.455 | 2027 | |
| 36 | Harold Aspell | 2.455 | 2026 | |
| 39 | Stanley Roberts | 2.500 | 2050 | |
| 40 | Gilberto Cruz | 2.571 | 2040 | |
| 41 | José Rosas | 2.613 | 2027 | |
| 41 | Felipe Soto# | 2.613 | 2055 | |
| 43 | José Guerra | 2.634 | 2024 | |
| 43 | Félix Hernández | 2.634 | 2027 | |
| 45 | Norm MacDonald | 2.647 | 2030 | |
| 45 | Thomas Morrison | 2.647 | 2040 | |
| 47 | Reynaldo Limón | 2.700 | 2025 | |
| 47 | Carlos Valentín | 2.700 | 2025 | |
| 49 | Juan Rosales | 2.746 | 2028 | |
| 50 | Jorge Cintrón | 2.793 | 2026 | |
| 51 | Héctor García | 2.893 | 2029 | |
| 52 | Jesús Pacheco | 2.945 | 2024 | |
| 53 | Jimmy Greenwood | 2.950 | 2026 | |
| 54 | Abel Gibson | 2.972 | 2028 | |
| 55 | Ricardo Sánchez | 3.000 | 2038 | |
| 55 | Kurt Hanson | 3.000 | 2054 | |
| 57 | Ken Houston# | 3.150 | 2053 | |
| 58 | Manuel Trujillo | 3.156 | 2028 | |
| 59 | Daryl Drake | 3.176 | 2023 | |
| 60 | Curtis Barnes | 3.203 | 2029 | |
| 61 | Luis López | 3.240 | 2023 | |
| 61 | Martín Flores | 3.240 | 2027 | |
| 63 | Mike Singleton | 3.259 | 2029 | |
| 64 | Carlos López | 3.273 | 2030 | |
| 64 | Keith Forrest# | 3.273 | 2056 | |
| 66 | António González | 3.316 | 2028 | |
| 67 | José Gallegos | 3.375 | 2023 | |
| 67 | Carlos Pineda | 3.375 | 2039 | |
| 69 | Ricardo Jaramillo | 3.423 | 2029 | |
| 70 | Wes West | 3.500 | 2048 | |
| 71 | José Bermúdez | 3.506 | 2025 | |
| 72 | Dan Voelzke# | 3.522 | 2055 | |
| 73 | Chiang-hui Lou | 3.566 | 2027 | |
| 74 | Héctor Romero | 3.574 | 2024 | |
| 75 | José Pezina | 3.578 | 2023 | |
| 76 | Salvador Gonzáles | 3.600 | 2030 | |
| 77 | Pepe Castillo | 3.635 | 2026 | |
| 78 | Javier Velázquez | 3.724 | 2030 | |
| 79 | Giobbe Pozziano | 3.780 | 2026 | |
| 80 | Maurice Anslow | 3.789 | 2024 | |
| 81 | Jack Luna | 3.857 | 2027 | |
| 82 | Álex Nieves | 3.913 | 2028 | |
| 83 | Juan Martínez | 4.068 | 2026 | |
| 84 | George House | 4.247 | 2029 | |
| 85 | Curtis Barnes | 4.290 | 2030 | |
| 86 | Luis Yánez | 4.355 | 2028 | |
| 87 | Tristão Moita | 4.426 | 2029 | |
| 88 | Héctor Freitas | 4.558 | 2027 | |
| 89 | Carlos Contreras | 4.655 | 2025 | |
| 90 | Steven Clayton# | 4.673 | 2048 | |
| 91 | Pedro Cardoza | 4.696 | 2030 | |
| 92 | Alvin Anstey# | 4.737 | 2053 | |
| 93 | Jean Chaumont | 4.765 | 2030 | |
| 94 | Darby Howell | 4.909 | 2027 | |
| 95 | José Rodríguez | 4.944 | 2051 | |
| 96 | Miguel Brito | 5.062 | 2026 | |
| 97 | Fred Ackerman | 5.304 | 2024 | |
| 97 | Abel Curro | 5.304 | 2028 | |
| 97 | Juan Rodríguez | 5.304 | 2026 | |
| 100 | Ángel Alaniz | 5.311 | 2026 |
