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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Frank Boland | 1.161 | 2042-2052 | |
| 2 | Joël Ottoboni | 1.350 | 2039-2053 | |
| 3 | Eric Buckson# | 1.430 | 2046-2058 | |
| 4 | José Olivarez | 1.524 | 2022-2029 | |
| 5 | Augusto Morán | 1.688 | 2041-2050 | |
| 5 | Luis Rúbio | 1.688 | 2048-2057 | |
| 5 | Marco Vitalle | 1.688 | 2039-2049 | |
| 8 | Richard Lawrence# | 1.703 | 2051-2058 | |
| 9 | David Prigent# | 1.717 | 2053-2058 | |
| 10 | Augate Balun | 1.845 | 2032-2050 | |
| 11 | Jorge Huerta | 1.851 | 2036-2050 | |
| 12 | Mark Moore# | 1.871 | 2051-2058 | |
| 13 | Cornelio Lozano | 2.005 | 2040-2052 | |
| 14 | Luis Gracía* | 2.048 | 2028-2045 | |
| 15 | Dan Estrada | 2.100 | 2029-2036 | |
| 16 | Al Colbert | 2.102 | 2042-2054 | |
| 17 | Cristo Muñóz# | 2.250 | 2042-2058 | |
| 18 | Joost Breakwell | 2.298 | 2020-2034 | |
| 19 | António Hernández# | 2.300 | 2048-2057 | |
| 20 | Kenny Hill | 2.339 | 2023-2036 | |
| 21 | Ryosei Akiyama | 2.374 | 2035-2050 | |
| 22 | Nathaniel Davis# | 2.386 | 2045-2058 | |
| 23 | Salvador Barrón | 2.438 | 2021-2029 | |
| 24 | Juan Hernández | 2.455 | 2026-2036 | |
| 25 | Nobuhito Kan# | 2.471 | 2047-2058 | |
| 26 | Carlos Rosa | 2.477 | 2032-2039 | |
| 27 | José Gutiérrez | 2.480 | 2022-2036 | |
| 28 | León Ramírez | 2.526 | 2031-2039 | |
| 28 | Vassilis Zorba# | 2.526 | 2048-2058 | |
| 30 | Joey Budding | 2.551 | 2020-2033 | |
| 31 | Erik Brooks# | 2.585 | 2051-2058 | |
| 32 | José Martínez# | 2.592 | 2050-2058 | |
| 33 | Carlos Pineda | 2.610 | 2040-2051 | |
| 34 | Sergio Herrera# | 2.622 | 2048-2058 | |
| 35 | Amayas Moelling | 2.625 | 2039-2055 | |
| 36 | Eric Stevens# | 2.638 | 2052-2058 | |
| 37 | Lorenzo de' Medici | 2.640 | 2037-2056 | |
| 38 | Bob Coleman | 2.641 | 2033-2044 | |
| 38 | Dani García | 2.641 | 2041-2049 | |
| 40 | Mark Lolololo# | 2.647 | 2057-2058 | |
| 41 | Ji-e Woo# | 2.652 | 2054-2058 | |
| 42 | Mario Villarreal | 2.670 | 2033-2042 | |
| 43 | Aaron Anderson# | 2.681 | 2049-2058 | |
| 44 | Júlio Silva | 2.700 | 2033-2042 | |
| 45 | Adrian Custello# | 2.712 | 2047-2058 | |
| 46 | Steven Clayton# | 2.732 | 2049-2058 | |
| 47 | Derrick Chaney# | 2.739 | 2045-2058 | |
| 48 | José Torres | 2.750 | 2034-2044 | |
| 49 | Alfredo Granados | 2.755 | 2026-2036 | |
| 50 | Luis Ramos# | 2.769 | 2049-2058 | |
| 51 | Denis Pham | 2.779 | 2033-2045 | |
| 52 | Kinzo Iwamoto# | 2.782 | 2048-2058 | |
| 53 | Ricardo Rivera | 2.799 | 2039-2058 | |
| 54 | Brian King | 2.802 | 2043-2055 | |
| 55 | Shawn Huber* | 2.822 | 2031-2050 | |
| 56 | Ángel Hernández | 2.867 | 2039-2055 | |
| 57 | Jerry Stone# | 2.870 | 2052-2058 | |
| 58 | Gary Estes* | 2.873 | 2017-2035 | |
| 59 | Danya Tchekanov | 2.888 | 2038-2053 | |
| 60 | Ryosei Akahori | 2.893 | 2036-2045 | |
| 60 | Peter Grady | 2.893 | 2032-2043 | |
| 62 | Angus Trew# | 2.953 | 2047-2058 | |
| 63 | Mike Alexander# | 2.971 | 2046-2058 | |
| 64 | Jerry Pacy | 2.982 | 2039-2050 | |
| 65 | Gerardo Rea# | 3.000 | 2048-2058 | |
| 66 | Bill Constable# | 3.014 | 2044-2057 | |
| 67 | Mario González | 3.029 | 2021-2038 | |
| 68 | Stephen Clulow | 3.037 | 2032-2044 | |
| 69 | Randolph Marable# | 3.048 | 2048-2058 | |
| 70 | Renato Lacerda# | 3.052 | 2039-2058 | |
| 71 | Mark Watson | 3.057 | 2022-2037 | |
| 72 | Tully Crow | 3.075 | 2022-2037 | |
| 73 | Reynaldo Garza | 3.076 | 2020-2036 | |
| 74 | Kevin Morales | 3.077 | 2032-2048 | |
| 75 | Alejandro Ramírez | 3.079 | 2035-2046 | |
| 76 | Manuel Ramírez* | 3.090 | 2018-2035 | |
| 77 | Ollie Lowry# | 3.108 | 2050-2058 | |
| 78 | Billy Chapel, Jr.* | 3.115 | 2017-2034 | |
| 79 | Manuel Barrera# | 3.135 | 2045-2058 | |
| 80 | Rubén Vázquez# | 3.173 | 2043-2058 | |
| 81 | Félix Alvarado | 3.176 | 2026-2040 | |
| 81 | Sam Romero | 3.176 | 2027-2038 | |
| 83 | Stephen Taub | 3.218 | 2036-2050 | |
| 84 | Jimmy Greenwood | 3.226 | 2028-2044 | |
| 85 | Luis Espinoza | 3.234 | 2021-2036 | |
| 86 | Ken Walter | 3.240 | 2033-2048 | |
| 87 | Danny Leach# | 3.253 | 2041-2058 | |
| 88 | Manuel Cruz | 3.264 | 2040-2054 | |
| 88 | Juan López | 3.264 | 2020-2030 | |
| 90 | Mick Hanscombe | 3.265 | 2016-2030 | |
| 91 | Josh Henson | 3.302 | 2042-2048 | |
| 92 | Chin Kim | 3.311 | 2033-2045 | |
| 93 | Jesús Feliciano | 3.318 | 2022-2034 | |
| 94 | Alfredo Chávez | 3.320 | 2022-2035 | |
| 95 | Jay Hodge# | 3.322 | 2046-2058 | |
| 96 | Pepe Jaramillo | 3.335 | 2032-2044 | |
| 97 | Francisco Medina | 3.337 | 2016-2030 | |
| 98 | Joe King# | 3.339 | 2052-2058 | |
| 99 | Anthony Jones# | 3.343 | 2050-2058 | |
| 100 | José Arellano | 3.348 | 2037-2054 |
