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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Postseason Career Leaderboard |
|---|---|---|---|---|
| 1 | Keith Kinnear# | 0.000 | 2048 | |
| 1 | Ash Malone | 0.000 | 2033 | |
| 3 | Gerald Sizemore | 0.587 | 2044 | |
| 3 | Ichizo Yamasaki# | 0.587 | 2050 | |
| 5 | José Bray# | 0.600 | 2049 | |
| 5 | Mark Reardon# | 0.600 | 2052 | |
| 7 | Chris Drover | 0.720 | 2026 | |
| 8 | Mark Lolololo# | 0.885 | 2056 | |
| 9 | Allen Gunn | 1.125 | 2044 | |
| 9 | Han-lee Kim | 1.125 | 2038 | |
| 11 | António Salazar | 1.149 | 2023 | |
| 12 | Ramón Mendoza | 1.174 | 2023 | |
| 13 | Ramón Gonzáles | 1.306 | 2030 | |
| 14 | Juan Jose Fuentes | 1.588 | 2033 | |
| 15 | Tony Canales | 1.636 | 2024 | |
| 16 | Lodewijk Kluin | 1.653 | 2027 | |
| 16 | Lodewijk Kluin | 1.653 | 2032 | |
| 18 | Garth Gunn# | 1.688 | 2055 | |
| 18 | Fernando Ferretti# | 1.688 | 2053 | |
| 20 | Juan Garza# | 1.723 | 2058 | |
| 21 | Cisco Morales | 1.770 | 2028 | |
| 22 | Clay Bingham | 1.800 | 2046 | |
| 22 | José Rodríguez | 1.800 | 2034 | |
| 22 | Jim Fields# | 1.800 | 2057 | |
| 25 | Ramón Guerrero | 1.862 | 2043 | |
| 26 | Alberto Magana | 1.875 | 2029 | |
| 27 | César Ramos | 1.884 | 2028 | |
| 27 | Frank Fuller | 1.884 | 2023 | |
| 27 | Jeff Brantley | 1.884 | 2028 | |
| 30 | António Hernández# | 1.895 | 2047 | |
| 31 | Cristián García | 1.929 | 2040 | |
| 32 | Félix García | 2.045 | 2028 | |
| 33 | Charles van Es | 2.160 | 2029 | |
| 34 | Corbin Valentín | 2.213 | 2042 | |
| 35 | Jon Reed | 2.250 | 2031 | |
| 35 | Rafael Salgado | 2.250 | 2024 | |
| 37 | Juan Ruíz | 2.348 | 2049 | |
| 38 | Juan Álvarez | 2.400 | 2047 | |
| 39 | Malcolm Jolly# | 2.455 | 2055 | |
| 40 | Ed Noble# | 2.547 | 2052 | |
| 40 | Jimmy Greenwood | 2.547 | 2028 | |
| 40 | Raúl Sánchez | 2.547 | 2025 | |
| 43 | Jesús Marte | 2.571 | 2029 | |
| 43 | Mark Reardon# | 2.571 | 2056 | |
| 45 | Luis Cabrera | 2.647 | 2023 | |
| 46 | Kit Venizelos# | 2.656 | 2057 | |
| 47 | Carter Curtis | 2.700 | 2028 | |
| 48 | José Morales | 2.727 | 2028 | |
| 49 | Jesús Vargas | 2.734 | 2027 | |
| 50 | Tom Young | 2.739 | 2023 | |
| 51 | Bingo Long | 2.755 | 2026 | |
| 52 | Roberto Vargas | 2.761 | 2028 | |
| 52 | Stanley Benson | 2.761 | 2025 | |
| 54 | Morris Chapa# | 2.779 | 2057 | |
| 55 | Brenton Breadalbane | 2.805 | 2026 | |
| 56 | Jorge Cintrón | 2.812 | 2028 | |
| 57 | Anastasio Quintana | 2.842 | 2024 | |
| 58 | Tokimasa Ihara | 2.893 | 2042 | |
| 59 | Germán Gómez | 2.908 | 2030 | |
| 60 | Cristóbal Hernández | 2.912 | 2028 | |
| 61 | Hyun-sik Chang | 2.919 | 2031 | |
| 62 | Daniel González# | 2.945 | 2045 | |
| 62 | Gord Downie | 2.945 | 2030 | |
| 64 | Stanley Kowalski# | 3.000 | 2051 | |
| 64 | Román Sánchez | 3.000 | 2041 | |
| 64 | José Núñez# | 3.000 | 2047 | |
| 64 | Jesús Vargas | 3.000 | 2026 | |
| 64 | Carlos Granados | 3.000 | 2046 | |
| 64 | Allen Price | 3.000 | 2030 | |
| 70 | Fernando Pacheco | 3.115 | 2028 | |
| 71 | François Mangin | 3.176 | 2039 | |
| 71 | Perry Wallace# | 3.176 | 2057 | |
| 73 | Yoshitaka Nishimura | 3.203 | 2048 | |
| 73 | Harold Lane | 3.203 | 2030 | |
| 75 | Charles van Es | 3.240 | 2027 | |
| 75 | Javier Delgado | 3.240 | 2034 | |
| 77 | Arturo Reyes | 3.259 | 2029 | |
| 78 | Santiago Pérez | 3.273 | 2036 | |
| 79 | Domingo Campa | 3.284 | 2026 | |
| 80 | Felipe Rosado | 3.306 | 2042 | |
| 81 | Samir Qasim# | 3.375 | 2056 | |
| 81 | Tony Nelson | 3.375 | 2028 | |
| 81 | Cristián Apodaca | 3.375 | 2027 | |
| 81 | José Chávez | 3.375 | 2023 | |
| 85 | Anastasio Vázquez | 3.453 | 2026 | |
| 86 | Jorge Cintrón | 3.484 | 2027 | |
| 87 | José Torres | 3.500 | 2033 | |
| 88 | Javier Bautista | 3.578 | 2027 | |
| 89 | Tony Caraballo | 3.600 | 2035 | |
| 90 | Domingo Anaya | 3.706 | 2025 | |
| 91 | Jesús Sánchez | 3.738 | 2024 | |
| 92 | António Correa | 3.803 | 2025 | |
| 93 | Lee Cuthbertson | 3.857 | 2029 | |
| 93 | Martín Núñez | 3.857 | 2028 | |
| 95 | Mark McCray | 3.919 | 2032 | |
| 96 | Daisuke Tomita | 3.927 | 2024 | |
| 97 | Tsurayuki Yamaguchi | 3.938 | 2039 | |
| 98 | Terrence Kelly | 4.000 | 2042 | |
| 99 | Kevin Fowler | 4.050 | 2035 | |
| 99 | Ramón Garza | 4.050 | 2030 |
