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| Career Wins Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Wins | IP | Years | Single Season Leaderboard |
| 1. | Steve Nebraska * | 382 | 4774.3 | 1973-1991 | |
| 2. | Fernando Huertas | 242 | 3950.3 | 1976-1993 | |
| 3. | Ryan Dunne * | 228 | 3726.6 | 1973-1989 | |
| 4. | Bill Max * | 225 | 3376.3 | 1975-1989 | |
| 5. | Michael Mangual * | 215 | 3711.6 | 1975-1991 | |
| 6. | Jerry Syed * | 214 | 3129.3 | 1976-1990 | |
| 7. | Mark Bobovnik * | 210 | 2916.9 | 1979-1992 | |
| 8. | John Ross Riles, Jr. | 207 | 3041.3 | 1981-1994 | |
| 9. | Justin Alexander * | 204 | 3124.3 | 1976-1992 | |
| 10. | Johan Schmatzhagen * | 199 | 2760.7 | 1973-1984 | |
| 11. | Lorenzo Diaz | 196 | 3266.6 | 1974-1989 | |
| 12. | Braggo Franco | 192 | 3375.6 | 1978-1994 | |
| 13. | Sam Kirkpatrick | 186 | 2760.6 | 1982-1994 | |
| 14. | Claver Olmeda | 185 | 2892.3 | 1982-1993 | |
| Matt Ryan | 185 | 2679.3 | 1981-1993 | ||
| 16. | Kurt Stallwith * | 181 | 2594.6 | 1973-1984 | |
| 17. | Jose Ramos | 179 | 3214.3 | 1978-1993 | |
| 18. | Floyd Bannister | 178 | 2530.3 | 1983-1994 | |
| 19. | Roy Hobbs, Jr. * | 177 | 2738.9 | 1973-1982 | |
| 20. | Paul Khalil | 176 | 2825.6 | 1977-1992 | |
| 21. | Corey Aubrey | 174 | 2613.9 | 1974-1988 | |
| 22. | Gerardo Caputo | 173 | 3121.9 | 1974-1990 | |
| 23. | Hank Daniels | 165 | 2509.3 | 1984-1994 | |
| Mark Fidrych | 165 | 2746.3 | 1978-1991 | ||
| 25. | Olen Eoff | 164 | 2836.3 | 1978-1992 | |
| Julio Guillerma | 164 | 2613.0 | 1973-1983 | ||
| 27. | Isidro Guiterrez | 163 | 2714.6 | 1982-1994 | |
| Mike Madorin | 163 | 3037.3 | 1973-1985 | ||
| 29. | Chuck Schaller | 162 | 3137.9 | 1973-1988 | |
| 30. | Kevin Robinson | 160 | 2871.0 | 1973-1990 | |
| 31. | Alex Lopez | 159 | 2767.0 | 1978-1991 | |
| 32. | Evander Kilkenny | 156 | 2523.0 | 1983-1994 | |
| 33. | Lincoln Hoots | 155 | 2677.6 | 1976-1992 | |
| 34. | Tex Avery | 154 | 2488.6 | 1981-1993 | |
| 35. | Timothy Regina | 152 | 2196.9 | 1982-1994 | |
| 36. | Henry Ellis | 151 | 2374.3 | 1983-1994 | |
| 37. | Marcel Reyes | 147 | 2479.3 | 1979-1992 | |
| 38. | Frank Rogers | 144 | 2506.3 | 1974-1988 | |
| Ron Vivero | 144 | 2697.0 | 1973-1983 | ||
| Voo Fowler | 144 | 2376.3 | 1973-1983 | ||
| 41. | Eric Beckmeyer | 143 | 2111.3 | 1979-1992 | |
| 42. | Francis Szabo | 142 | 2298.3 | 1976-1986 | |
| 43. | Bill Walters | 139 | 2567.6 | 1983-1994 | |
| 44. | Vernon Meyer | 136 | 2410.6 | 1978-1989 | |
| 45. | Ace Holder | 135 | 2293.6 | 1973-1982 | |
| 46. | Pete Redfern | 134 | 2120.3 | 1983-1994 | |
| Andy Messersmith | 134 | 2028.0 | 1976-1984 | ||
| 48. | James Watkins | 133 | 2420.3 | 1976-1988 | |
| 49. | Chuck Delong | 132 | 2391.6 | 1973-1984 | |
| 50. | Ed Ostrosser | 131 | 2400.3 | 1979-1990 | |
| Micheal Cassidy | 131 | 2316.6 | 1977-1988 | ||
| 52. | Tenchi Masaki | 130 | 2690.9 | 1977-1993 | |
| Darius Campbell | 130 | 2688.3 | 1977-1991 | ||
| Zachary Sumner | 130 | 2398.9 | 1973-1983 | ||
| 55. | Heath Rockefeller | 129 | 1776.3 | 1985-1994 | |
| 56. | Marcellus Conley | 128 | 2180.0 | 1973-1981 | |
| 57. | Hayden Finch | 127 | 2281.6 | 1983-1994 | |
| 58. | Ken Howell | 125 | 1817.6 | 1984-1994 | |
| Lewis Bauder | 125 | 2298.6 | 1980-1993 | ||
| David Lillis | 125 | 2337.9 | 1976-1987 | ||
| Pete Bucher | 125 | 2229.6 | 1973-1984 | ||
| 62. | Denny Wegman | 124 | 2269.0 | 1980-1994 | |
| Floyd Futon | 124 | 2181.9 | 1982-1994 | ||
| Todd Adams | 124 | 2268.0 | 1975-1988 | ||
| Jackie Varela | 124 | 2448.6 | 1975-1985 | ||
| 66. | Shamus Perfetto | 123 | 2081.6 | 1984-1994 | |
| Narciso Jarilla | 123 | 1864.3 | 1973-1982 | ||
| 68. | Tim Bombardier | 122 | 2057.3 | 1982-1994 | |
| Al Nipper | 122 | 1918.3 | 1984-1994 | ||
| Juan Verde | 122 | 1821.6 | 1977-1990 | ||
| 71. | Robert Grove | 121 | 2018.3 | 1984-1994 | |
| Hector Salazar | 121 | 2099.6 | 1979-1989 | ||
| Jamaal Jumboni | 121 | 1939.0 | 1973-1982 | ||
| 74. | Hi Brown | 118 | 1854.0 | 1985-1994 | |
| Mickey Ford | 118 | 2288.0 | 1976-1986 | ||
| Junior Gomez | 118 | 2057.0 | 1973-1982 | ||
| 77. | Vernon Simpson * | 117 | 1575.7 | 1973-1978 | |
| 78. | Raymond Woodruff | 114 | 1943.3 | 1981-1992 | |
| 79. | Guy Corngood | 113 | 2141.0 | 1984-1994 | |
| Larry Trinkle | 113 | 2189.0 | 1976-1989 | ||
| 81. | Terrence Williams | 112 | 1835.0 | 1976-1984 | |
| 82. | Avagadro Pompeii | 111 | 1798.3 | 1984-1994 | |
| Cesar Tostado | 111 | 2043.3 | 1975-1985 | ||
| Bobby Carey | 111 | 1927.0 | 1975-1985 | ||
| 85. | Phil Longwell | 110 | 2163.6 | 1982-1994 | |
| 86. | Ivan Aguilera | 109 | 1659.3 | 1977-1988 | |
| 87. | Darius Widowmaker | 108 | 2188.6 | 1981-1994 | |
| Albert Camarena | 108 | 2009.6 | 1984-1994 | ||
| 89. | Ray Fontenot | 107 | 2093.6 | 1983-1994 | |
| Ricky Knutsen | 107 | 1853.6 | 1984-1994 | ||
| Kevin Saucier | 107 | 1823.9 | 1983-1994 | ||
| 92. | Sol Hernandez | 106 | 1914.3 | 1975-1987 | |
| Denny Estrada | 106 | 1850.6 | 1973-1980 | ||
| 94. | Al Bowsfield | 105 | 2135.0 | 1982-1994 | |
| Gil Daniels | 105 | 1508.0 | 1983-1994 | ||
| Jerry Neal | 105 | 1891.9 | 1980-1993 | ||
| 97. | J.R. Richard | 104 | 1764.0 | 1981-1989 | |
| Alonso Cruz | 104 | 1623.6 | 1978-1986 | ||
| Arky Mooris | 104 | 1829.0 | 1973-1981 | ||
| 100. | Larry Gorton | 103 | 1995.3 | 1973-1982 |
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