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| Career Strikeouts Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Strikeouts | IP | Years | Single Season Leaderboard |
| 1. | Steve Nebraska * | 6156 | 4774.3 | 1973-1991 | |
| 2. | Fernando Huertas | 3969 | 3950.3 | 1976-1993 | |
| 3. | Roy Hobbs, Jr. * | 3156 | 2738.9 | 1973-1982 | |
| 4. | Michael Mangual * | 3004 | 3711.6 | 1975-1991 | |
| 5. | Justin Alexander * | 2964 | 3124.3 | 1976-1992 | |
| 6. | Braggo Franco | 2922 | 3375.6 | 1978-1994 | |
| Johan Schmatzhagen * | 2922 | 2760.7 | 1973-1984 | ||
| 8. | Mark Bobovnik * | 2874 | 2916.9 | 1979-1992 | |
| 9. | Hayden Finch | 2869 | 2281.6 | 1983-1994 | |
| 10. | Lorenzo Diaz | 2836 | 3266.6 | 1974-1989 | |
| 11. | Bill Max * | 2787 | 3376.3 | 1975-1989 | |
| 12. | Voo Fowler | 2784 | 2376.3 | 1973-1983 | |
| 13. | Jerry Syed * | 2747 | 3129.3 | 1976-1990 | |
| 14. | Tenchi Masaki | 2693 | 2690.9 | 1977-1993 | |
| 15. | Corey Aubrey | 2666 | 2613.9 | 1974-1988 | |
| 16. | John Ross Riles, Jr. | 2640 | 3041.3 | 1981-1994 | |
| 17. | Olen Eoff | 2597 | 2836.3 | 1978-1992 | |
| 18. | Chuck Schaller | 2576 | 3137.9 | 1973-1988 | |
| 19. | Lincoln Hoots | 2511 | 2677.6 | 1976-1992 | |
| 20. | Ryan Dunne * | 2469 | 3726.6 | 1973-1989 | |
| 21. | Gerardo Caputo | 2447 | 3121.9 | 1974-1990 | |
| 22. | Bill Walters | 2444 | 2567.6 | 1983-1994 | |
| 23. | Sam Kirkpatrick | 2400 | 2760.6 | 1982-1994 | |
| 24. | David Lillis | 2358 | 2337.9 | 1976-1987 | |
| 25. | Henry Ellis | 2344 | 2374.3 | 1983-1994 | |
| 26. | James Watkins | 2338 | 2420.3 | 1976-1988 | |
| 27. | Zachary Sumner | 2330 | 2398.9 | 1973-1983 | |
| 28. | Hank Daniels | 2309 | 2509.3 | 1984-1994 | |
| 29. | Jose Ramos | 2293 | 3214.3 | 1978-1993 | |
| 30. | Alex Lopez | 2286 | 2767.0 | 1978-1991 | |
| 31. | Kurt Stallwith * | 2259 | 2594.6 | 1973-1984 | |
| 32. | Jim McGraw | 2235 | 2062.0 | 1973-1984 | |
| 33. | Matt Ryan | 2223 | 2679.3 | 1981-1993 | |
| 34. | Micheal Cassidy | 2178 | 2316.6 | 1977-1988 | |
| 35. | Jackie Varela | 2173 | 2448.6 | 1975-1985 | |
| 36. | Marcellus Conley | 2144 | 2180.0 | 1973-1981 | |
| 37. | Narciso Jarilla | 2129 | 1864.3 | 1973-1982 | |
| 38. | Harvey Vitiello | 2113 | 1830.0 | 1974-1984 | |
| 39. | Francis Szabo | 2088 | 2298.3 | 1976-1986 | |
| 40. | Frank Rogers | 2085 | 2506.3 | 1974-1988 | |
| 41. | Tex Avery | 2081 | 2488.6 | 1981-1993 | |
| 42. | Vernon Meyer | 2027 | 2410.6 | 1978-1989 | |
| 43. | Floyd Bannister | 2016 | 2530.3 | 1983-1994 | |
| 44. | Darius Campbell | 2005 | 2688.3 | 1977-1991 | |
| 45. | Eric Beckmeyer | 1995 | 2111.3 | 1979-1992 | |
| 46. | Evander Kilkenny | 1989 | 2523.0 | 1983-1994 | |
| 47. | Robert Grove | 1961 | 2018.3 | 1984-1994 | |
| 48. | Kevin Robinson | 1949 | 2871.0 | 1973-1990 | |
| 49. | Denny Estrada | 1945 | 1850.6 | 1973-1980 | |
| 50. | Isidro Guiterrez | 1929 | 2714.6 | 1982-1994 | |
| 51. | Larry Gorton | 1910 | 1995.3 | 1973-1982 | |
| 52. | Bobby Carey | 1889 | 1927.0 | 1975-1985 | |
| 53. | Cesar Tostado | 1866 | 2043.3 | 1975-1985 | |
| 54. | Denny Wegman | 1856 | 2269.0 | 1980-1994 | |
| Ace Holder | 1856 | 2293.6 | 1973-1982 | ||
| 56. | Gustavo Aranda | 1845 | 1605.3 | 1974-1983 | |
| 57. | Jacinto Merino | 1839 | 1653.6 | 1976-1987 | |
| 58. | Kevin Saucier | 1833 | 1823.9 | 1983-1994 | |
| 59. | Pete Redfern | 1825 | 2120.3 | 1983-1994 | |
| 60. | Marcel Reyes | 1821 | 2479.3 | 1979-1992 | |
| 61. | Todd Adams | 1820 | 2268.0 | 1975-1988 | |
| 62. | Shamus Perfetto | 1795 | 2081.6 | 1984-1994 | |
| 63. | Billy Chapel | 1771 | 1708.6 | 1973-1980 | |
| 64. | Brock Rutherford | 1756 | 1685.0 | 1973-1979 | |
| 65. | Phil Longwell | 1755 | 2163.6 | 1982-1994 | |
| 66. | Paul Khalil | 1728 | 2825.6 | 1977-1992 | |
| 67. | Albert Diaz | 1706 | 1331.7 | 1975-1983 | |
| 68. | J.R. Richard | 1686 | 1764.0 | 1981-1989 | |
| 69. | Ron Vivero | 1668 | 2697.0 | 1973-1983 | |
| 70. | Allan Atkins | 1652 | 1413.3 | 1984-1994 | |
| 71. | Washington Jones | 1641 | 1761.0 | 1985-1994 | |
| 72. | Joaquin Contraveras | 1634 | 1489.0 | 1973-1979 | |
| 73. | Jacob Butler | 1616 | 1811.0 | 1975-1983 | |
| 74. | Hi Brown | 1614 | 1854.0 | 1985-1994 | |
| 75. | Claver Olmeda | 1610 | 2892.3 | 1982-1993 | |
| 76. | Ed Ostrosser | 1607 | 2400.3 | 1979-1990 | |
| 77. | Chuck Delong | 1606 | 2391.6 | 1973-1984 | |
| 78. | Floyd Futon | 1596 | 2181.9 | 1982-1994 | |
| 79. | Darius Widowmaker | 1592 | 2188.6 | 1981-1994 | |
| 80. | Julio Guillerma | 1585 | 2613.0 | 1973-1983 | |
| 81. | Pete Bucher | 1582 | 2229.6 | 1973-1984 | |
| 82. | Albert Camarena | 1578 | 2009.6 | 1984-1994 | |
| 83. | Heath Rockefeller | 1568 | 1776.3 | 1985-1994 | |
| 84. | Mickey Ford | 1561 | 2288.0 | 1976-1986 | |
| 85. | Bill Microsoft | 1546 | 1786.3 | 1983-1994 | |
| 86. | Ricky Knutsen | 1529 | 1853.6 | 1984-1994 | |
| 87. | Ken Howell | 1511 | 1817.6 | 1984-1994 | |
| 88. | Hank Davidson | 1509 | 1583.9 | 1984-1994 | |
| Ricky Vaughn | 1509 | 1188.6 | 1973-1981 | ||
| 90. | Mike Madorin | 1495 | 3037.3 | 1973-1985 | |
| 91. | Junior Gomez | 1491 | 2057.0 | 1973-1982 | |
| 92. | Timothy Regina | 1486 | 2196.9 | 1982-1994 | |
| 93. | Luke Nastay | 1480 | 1486.0 | 1984-1994 | |
| 94. | Hector Salazar | 1471 | 2099.6 | 1979-1989 | |
| 95. | Stephen Thiel | 1461 | 1663.6 | 1981-1991 | |
| 96. | Lewis Bauder | 1456 | 2298.6 | 1980-1993 | |
| 97. | Alonso Cruz | 1452 | 1623.6 | 1978-1986 | |
| 98. | Mark Catron | 1447 | 1487.3 | 1975-1983 | |
| 99. | Terrence Williams | 1442 | 1835.0 | 1976-1984 | |
| 100. | Guy Corngood | 1433 | 2141.0 | 1984-1994 |
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